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Congenital Mesoblastic Nephroma Presenting with Neonatal Hypertension

Journal of Perinatology volume 25, pages 433–435 (2005)Cite this article

Congenital mesoblastic nephroma (CMN) is a rare tumor with an estimated incidence of about 8/million in children under 15 years of life.1 It is, however, the most common renal tumor in neonates, with more than 80% of CMN tumors presenting in the neonatal period.2 In 1967, Bolande et al.3 described CMN as a separate entity from congenital Wilms' tumor and it is now considered a generally benign renal tumor (as opposed to its variant, the atypical mesoblastic nephroma; AMN). Nephrectomy alone is the treatment of choice with a reported survival of over 98%.4

Hypertension has been reported with many renal tumors, with or without hyper-reninemia. To date, only nine patients with CMN and hypertension have been reported, out of which six were neonates.5, 6 We describe the clinical presentation and discuss the findings on abdominal imaging in a 30-week gestation infant with hypertension and CMN.

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Authors and Affiliations

  1. Division of Neonatology, Department of Pediatrics, Children's and Women's Health Centre of British Columbia and University of British Columbia, Vancouver, BC, Canada

    Minesh Khashu MD, MRCPCH & Horacio Osiovich MD, FRCPC

  2. Department of Radiology, Children's and Women's Health Centre of British Columbia & University of British Columbia, Vancouver, BC, Canada

    Michael A Sargent MD, FRCPC

Authors
  1. Minesh Khashu MD, MRCPCH
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  2. Horacio Osiovich MD, FRCPC
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  3. Michael A Sargent MD, FRCPC
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Khashu, M., Osiovich, H. & Sargent, M. Congenital Mesoblastic Nephroma Presenting with Neonatal Hypertension. J Perinatol 25, 433–435 (2005). https://doi.org/10.1038/sj.jp.7211304

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