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  • Perinatal/Neonatal Casebook
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Perinatal/Neonatal Case Book

Caudal Regression Syndrome in Twin Pregnancy With Type II Diabetes

Journal of Perinatology volume 22, pages 171–174 (2002)Cite this article

Abstract

Caudal Regression Syndrome (CRS) is a rare fetal complication of diabetic pregnancy, which can result in long-term neurological, urologic, and orthopedic complications. Although the exact teratogenic mechanism is not known, hyperglycemia appears to play a crucial role as a teratogen, and therefore, stringent control of diabetes preconceptually and in early pregnancy is presumed to reduce the risk of occurrence. We report an unusual case of CRS affecting only one of a set of monozygotic twins, suggesting that as yet, unidentified factors other than hyperglycemia are included in its causation.

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Acknowledgements

We thank P. J. Helms and O. daSilva for reviewing the manuscript, and the Department of Medical Illustration at the Medical School, University of Aberdeen, for preparing the photographs.

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Authors and Affiliations

  1. Department of Child Health, University of Aberdeen, Foresterhill, Aberdeen, Scotland, UK

    Win Zaw MBBS, MRCP

  2. Neonatal Unit, Aberdeen Maternity Hospital, Cornhill Road, Aberdeen, UK

    David G Stone FRACP

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  1. Win Zaw MBBS, MRCP
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  2. David G Stone FRACP
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Zaw, W., Stone, D. Caudal Regression Syndrome in Twin Pregnancy With Type II Diabetes. J Perinatol 22, 171–174 (2002). https://doi.org/10.1038/sj.jp.7210614

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