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Effects of Continuous Positive Airway Pressure on Diaphragm Dimensions in Preterm Infants

Journal of Perinatology volume 21, pages 521–524 (2001)Cite this article

Abstract

OBJECTIVE:The use of continuous positive airway pressure (CPAP) in the treatment of a variety of neonatal respiratory conditions is associated with improvement in arterial oxygen saturation, decreased long-term morbidity, and an overall improvement in infant survival. We reasoned that CPAP might change diaphragm length by increasing end-expiratory lung volume (EEV), but the extent to which this occurs has not been assessed. This study was designed to evaluate (1) the extent to which CPAP shortens the diaphragm and (2) the relationship of diaphragm thickness and excursion with arterial oxygen saturation in spontaneously breathing preterm infants.

STUDY DESIGN:Ultrasonographically (7.5 MHz transducer), diaphragm thickness and diaphragm excursion were measured in 12 stable preterm infants [birth weight 1120±225 g (mean±SD); study weight 1187±400 g; gestational age 29±1 week; postnatal age 10±8 days, six males and six females] at three levels of CPAP [1–3, 4–6, and 7–9 cm H2O (low, medium, and high, respectively)]. Heart rate, respiratory rate, and arterial oxygen saturation were simultaneously recorded.

RESULTS:We found that diaphragm thickness and arterial oxygen saturation increased, and diaphragm excursion decreased significantly at higher levels of CPAP (p<0.05). The shortening of the diaphragm at the high levels of CPAP, calculated from the increase in diaphragm thickness, was 36% at EEV and 31% at end-inspiratory volume.

CONCLUSION:We conclude that the improvement in arterial oxygen saturation with CPAP occurred despite the presence of a shorter and a less mobile diaphragm, and that other physiological and mechanical alterations accompanying the application of CPAP offset its negative effects on diaphragm function. We speculate that with excessive CPAP, however, diaphragm dysfunction along with the previously described adverse hemodynamic effects may outweigh its benefits on oxygenation.

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Authors and Affiliations

  1. Department of Pediatrics, Memorial Hospital of Rhode Island, Pawtucket, RI, USA

    Virender K Rehan MD & Joann Laiprasert

  2. Department of Pathology, Memorial Hospital of Rhode Island, Pawtucket, RI, USA

    James M Nakashima PhD

  3. Departments of Pediatrics and Radiology, Women and Infants' Hospital, Brown University School of Medicine, Providence, RI, USA

    Michael Wallach MD

  4. Department of Medicine, Memorial Hospital of Rhode Island, Pawtucket, RI, USA

    Franklin D McCool MD

Authors
  1. Virender K Rehan MD
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  2. Joann Laiprasert
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  3. James M Nakashima PhD
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  4. Michael Wallach MD
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  5. Franklin D McCool MD
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APPENDIX

APPENDIX

Calculation of diaphragm length (ldi) from diaphragm thickness (tdi):

where m, t, p, and l represent diaphragm mass, thickness, perimeter, and length, respectively. Assuming m and p are constant:

Therefore, change in diaphragm length from low and high CPAP can be obtained as follows:

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Rehan, V., Laiprasert, J., Nakashima, J. et al. Effects of Continuous Positive Airway Pressure on Diaphragm Dimensions in Preterm Infants. J Perinatol 21, 521–524 (2001). https://doi.org/10.1038/sj.jp.7210587

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