Abstract
4 patients with advanced non-small-cell lung cancer (NSCLC) treated with docetaxel developed life-threatening pneumonitis requiring mechanical ventilation. Docetaxel (30–60 mg m–2, according to a different protocol) was infused within one hour with standard premedications. One patient’s pneumonitis occurred 5 days after the first dose of docetaxel, and that of the other 3 between the 2nd and 6th cycles. Based on the clinical course, radiological findings of an interstitial pneumonitis, and exclusion of other possible resultant causes, including metastatic cancer, radiation pulmonary injury, infection, or connective tissue disease, hypersensitivity pneumonitis was diagnosed. The patients were treated with hydrocortisone at 1200 mg per day or methylprednisolone at 240 mg per day. Although 3 of the 4 had a partial improvement in lung oxygenation, all patients’ conditions of hypersensitivity pneumonitis persisted and were complicated by other events, such as hospital-acquired infection and tension pneumothorax. The presence of this unusual hypersensitivity pneumonitis, which was so severe as to be life-threatening and refractory to high-dose corticosteroid therapy, should be taken into account during docetaxel treatment. © 2001 Cancer Research Campaign www.bjcancer.com
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References
Akoun GM, Milleron BJ, Mayaud CM and Tholoniat D (1989) Provocation test coupled with bronchoalveolar lavage in diagnosis of propanolol-induced hypersensitivity pneumonitis. Am Rev Respir Dis 139: 247–249
Akoun GM, Liote HA, Liote F, Rahman SG and Juntz D (1990) Provocation test coupled with bronchoalveolar lavage in diagnosis of drug (Nilutamide)-induced hypersensitivity pneumonitis. Chest 97: 495–498
Choy H, Safran J, Akerley W, Graziano SL, Bogart JA and Cole BF (1998) Phase II trial of weekly paclitaxel and concurrent radiation therapy for locally advanced non-small-cell lung cancer. Clin Cancer Res 4: 1931–1936
Cooper JR JAD, White DA and Matthay RA (1986a) Drug-induced pulmonary disease. Part 1: Cytotoxic drugs. Am Rev Respir Dis 133: 321–340
Cooper JRJAD, White DA and Matthay RA (1986b) Drug-induced pulmonary disease. Part 2: Noncytotoxic drugs. Am Rev Respir Dis 133: 488–505
Earhart RH (1999) Docetaxel (Taxotere): Preclinical and general clinical information. Semin Oncol 26, (Suppl 17):8–13
Etienne B, Perol M, Nesme P, Vuillermoz S, Robinet G and Guerin JC (1998) Pneumopathie interstitielle diffuse aigue sous docetaxel (Taxotere). A propos de 2 observations. Rev Mal Respir 15: 199–203, [French; abstract in English]
Fossella FV (1999) Docetaxel in the treatment of non-small-cell lung cancer: Review of single-agent trials. Semin Oncol 26, (Suppl 16):17–23
Fujimori K, Yokoyama A, Kurita Y, Uni K and Saijo N (1998) Paclitaxel-induced cell-mediated hypersensitivity pneumonitis. Diagnosis using leukocyte migration test, bronchoalveolar lavage and transbronchial lung biopsy. Oncology 55: 340–344
Furuse K, Naka N, Takada M, Kinuwaki E, Kudo S, Takada Y, Yamakido M, Yamamoto H and Fukuoka M (1997) Phase II study of 3-hour infusion of paclitaxel in patients with previously untreated stage III and IV non-small-cell lung cancer. Oncology 54: 298–303
Guillon JM, Joly P, Austran B, Denis M, Akoun G, Debre P and Mayaud C (1992) Minocycline-induced cell-mediated hypersensitivity pneumonitis. Ann Int Med 117: 476–481
Helmers RA and Pisani RJ (1994) Bronchoscopy. In Chaper 13:Bronchoalveolar lavage, Prakash UBS (ed). pp 155–182. Mayo Foundation, Published by Raven Press, Ltd., New York
Holoye PY, Luna MA, Mackay B and Bedrossian CWM (1978) Bleomycin hypersensitivity pneumonitis. Ann Int Med 88: 47–49
Ibrahim JK, Sahin AA, Dubrow RA, Lynch RM, Michaud LB, Valero V, Buzdar AU and Hortobagyi GN (2000) Colitis associated with docetaxel-based chemotherapy in patients with metastatic breast cancer. Lancet 355: 281–283
Jantz MA and Sahn SA (1999) Corticosteroids in acute respiratory failure. Am J Respir Crit Care Med 160: 1079–1100
Keller RH, Swartz S, Schlueter DP, Bar-Sela S and Fink JN (1984) Immunoregulation in hypersensitivity pneumonitis: phenotypic and functional studies of bronchoalveolar lavage lymphocytes. Am Rev Respir Dis 130: 766–771
Khan A, McNally D, Tutschka PJ and Bilgrami S (1997) Paclitaxel-induced acute bilateral pneumonitis. Ann Pharmacother 31: 1471–1474
Kunitah H, Watanabe K, Onoshi T, Furuse K, Niitani H and Taguchi T (1996) Phase II trial of docetaxel in previously untreated advanced non- small-cell lung cancer: A Japanese cooperative study. J Clin Oncol 14: 1649–1655
Merad M, Cesne AL, Baldeyrou P, Mesurolle B and Chevalier TL (1997) Docetaxel and interstitial pulmonary injury. Ann Oncol 8: 191–194
Munster PN and Hudis CA (2000) Role of taxanes in adjuvant therapy. Cancer inve 18: 32–38
Schweitzer VG, Juilard GJF, Bajada CL and Parker RG (1995) Radiation recall dermatitis and pneumonitis in a patient treated with paclitaxel. Cancer 76: 1069–1072
Tamura T, Sasaki Y, Nishiwaki Y and Saijo N (1995) Phase I study of paclitaxel by three-hour infusion: hypotension just after infusion is one of the major dose-limiting toxicities. Jpn J Cancer Res 86: 1203–1209
Vaishampayan U, Parchment RE, Jasti BR and Jussain M (1999) Taxanes: An overview of the pharmacokinetics and pharmacodynamics. Urology 54, (Suppl 6A):22–29
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Wang, GS., Yang, KY. & Perng, RP. Life-threatening hypersensitivity pneumonitis induced by docetaxel (taxotere). Br J Cancer 85, 1247–1250 (2001). https://doi.org/10.1054/bjoc.2001.2071
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DOI: https://doi.org/10.1054/bjoc.2001.2071
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