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Examination of seven candidate regions for multiple sclerosis: strong evidence of linkage to chromosome 1q44

Genes & Immunity volume 7, pages 73–76 (2006)Cite this article

Abstract

Multiple sclerosis (MS) is a debilitating neuroimmunological and neurodegenerative disease with a strong genetic component. Numerous studies have failed to consistently identify genes that confer disease susceptibility except for association with HLA-DR. Seven non-HLA regions (1q, 2q, 9q, 13q, 16q, 18p and 19q) identified in a recent genomic screen were investigated by genotyping ∼20 single-nucleotide polymorphisms (SNPs) at ∼1 Mb intervals. Non-parametric multipoint analyses identified a peak LOD* score of 2.99 for the 1q44 region and substantially narrowed the linkage peak to ∼7 Mb. Ordered subset analyses (OSA) identified significant LOD score increases for 2q35 and 18p11 when ranking families by HLA-DR status and identified a significant LOD score increase in region 2q35 when ranking families by linkage to chromosome 1q44. 1q44 is particularly interesting because of linkage evidence for this region in studies of both rheumatoid arthritis and systemic lupus erythematosus.

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Acknowledgements

We like to express our appreciation to all of the families who generously participated in this study. We would also like to thank the collaborating clinics and clinicians for referring individuals to the study. This study was supported by the following grants: National Multiple Sclerosis Society RG 2899, NIH NS32380, NIH NS26799, and the Nancy Davis Centers Without Walls Foundation.

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Authors and Affiliations

  1. Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN, USA

    S J Kenealy, L A Herrel, Y Bradford, N Schnetz-Boutaud & J L Haines

  2. Department of Neurology, University of California San Francisco, San Francisco, CA, USA

    J R Oksenberg & S L Hauser

  3. Division of Public Health-Epidemiology, University of California, Berkeley, CA, USA

    L F Barcellos

  4. Center for Human Genetics, Duke University Medical Center, Durham, NC, USA

    S Schmidt, S G Gregory & M A Pericak-Vance

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  1. S J Kenealy
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Correspondence to J L Haines.

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Kenealy, S., Herrel, L., Bradford, Y. et al. Examination of seven candidate regions for multiple sclerosis: strong evidence of linkage to chromosome 1q44. Genes Immun 7, 73–76 (2006). https://doi.org/10.1038/sj.gene.6364275

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  • DOI: https://doi.org/10.1038/sj.gene.6364275

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