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Combined haplotype analysis of the interleukin-19 and -20 genes: relationship to plaque-type psoriasis

Genes & Immunity volume 5, pages 662–667 (2004)Cite this article

Abstract

There is increasing evidence to suggest that the newly discovered cytokines interleukin (IL)-19 and -20 have a role in the function of epidermis and in psoriasis. The genes encoding these cytokines locate into the genomic IL-10 region on human chromosome 1. The aim of the present study was to analyze whether single-nucleotide polymorphisms (SNPs) in these genes have an impact on the susceptibility for psoriasis. From pairwise linkage disequilibrium (LD) matrix of the IL-19 and -20 gene polymorphisms, what reflects the nonrandom association of alleles at these markers, it was apparent that IL-19 and -20 genes form one block of LD. We found that the HT3 CACCGGAA haplotype of the IL-19 and -20 genes was associated with an increased risk of psoriasis, reflecting its role in determining susceptibility to plaque-type psoriasis. Although association analysis of the IL-19 gene indicated that minor alleles of the IL-19 gene SNPs (rs2243188, rs2243169 and rs2243158) revealed protective effect to psoriasis and haplotype analysis of the IL-19 gene proved significant protective effect of the TGATA haplotype in case of late-onset disease, combined haplotype analysis of the IL-19 and -20 genes demonstrated that protective effect of the IL-19 gene is secondary to the susceptibility effect of the IL-20 gene.

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Acknowledgements

This study was supported by the target-based funding from the Estonian Ministry of Education Grant No. 0182128s02 (PARNH2128), by the Estonian Science Foundation Grants No. 5712 and 5688 and by the Centre of Molecular and Clinical Medicine Grant VARMC-TIPP.

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Authors and Affiliations

  1. Department of Physiology, University of Tartu, Tartu, Estonia

    S Kõks, R Rätsep & E Vasar

  2. Department of Dermatology and Venerology, University of Tartu, Tartu, Estonia

    K Kingo, M Karelson & H Silm

  3. Centre of Molecular and Clinical Medicine, University of Tartu, Tartu, Estonia

    S Kõks, K Kingo, R Rätsep & E Vasar

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  1. S Kõks
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  2. K Kingo
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Correspondence to S Kõks.

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Kõks, S., Kingo, K., Rätsep, R. et al. Combined haplotype analysis of the interleukin-19 and -20 genes: relationship to plaque-type psoriasis. Genes Immun 5, 662–667 (2004). https://doi.org/10.1038/sj.gene.6364141

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