Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


A genetic cause of age-related decline

Genetic variation in a neuropeptide signalling pathway regulates age-related declines in health in nematode worms. This discovery points to a mechanism that influences individual differences in ageing. See Article p.198

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Regulation of ageing-associated health declines.


  1. See all news & views


  1. International Human Genome Sequencing Consortium. Nature 409, 860–921 (2001).

  2. Venter, J. C. et al. Science 291, 1304–1351 (2001).

    Google Scholar 

  3. Yin, J.-A. et al. Nature 551, 198–203 (2017).

    ADS  CAS  Article  Google Scholar 

  4. Yin, J.-A., Liu, X.-J., Yuan, J., Jiang, J. & Cai, S.-Q. J. Neurosci. 34, 3947–3958 (2014).

    Article  Google Scholar 

  5. Bargmann, C. I. BioEssays 34, 458–465 (2012).

    CAS  Article  Google Scholar 

  6. Bendesky, A. et al. Nature 544, 434–439 (2017).

    ADS  CAS  Article  Google Scholar 

  7. de Bono, M. & Bargmann, C. I. Cell 94, 679–689 (1998).

    CAS  Article  Google Scholar 

  8. Lim, M. M. et al. Nature 429, 754–757 (2004).

    ADS  CAS  Article  Google Scholar 

  9. McGrath, P. T. Curr. Opin. Neurobiol. 23, 24–28 (2013).

    CAS  Article  Google Scholar 

  10. Araque, A. et al. Neuron 81, 728–739 (2014).

    CAS  Article  Google Scholar 

  11. Bäckman, L., Lindenberger, U., Li, S.-C. & Nyberg, L. Neurosci. Biobehav. Rev. 34, 670–677 (2010).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Patrick T. McGrath.

Related links

Related links

Related links in Nature Research

Ageing: A stretch in time

Ageing: When less is more

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

McGrath, P. A genetic cause of age-related decline. Nature 551, 179–180 (2017).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing