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Metastasis

Lymphatic detours for cancer

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The growth factor MIDKINE, which is secreted by skin tumours called melanomas, stimulates the formation of lymphatic vessels at distant lymph nodes and organ sites, paving the way for metastatic cancer spread. See Letter p.676

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Figure 1: A previously undiscovered route to metastasis.

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References

  1. Faries, M. B. et al. New Engl. J. Med. 376, 2211–2222 (2017).

    Article  Google Scholar 

  2. Olmeda, D. et al. Nature 546, 676–680 (2017).

    ADS  CAS  Article  Google Scholar 

  3. Petrova, T. V. et al. Cancer Cell 13, 554–556 (2008).

    CAS  Article  Google Scholar 

  4. Kaplan, R. N. et al. Nature 438, 820–827 (2005).

    ADS  CAS  Article  Google Scholar 

  5. Hoshino, A. et al. Nature 527, 329–335 (2015).

    ADS  CAS  Article  Google Scholar 

  6. Hirakawa, S. et al. Blood 109, 1010–1017 (2007).

    CAS  Article  Google Scholar 

  7. Peinado, H. et al. Nature Rev. Cancer 17, 302–317 (2017).

    CAS  Article  Google Scholar 

  8. Das, S. et al. Cancer Res. 70, 1814–1824 (2010).

    CAS  Article  Google Scholar 

  9. Muramatsu, T. & Kadomatsu, K. Br. J. Pharmacol. 171, 811–813 (2014).

    CAS  Article  Google Scholar 

  10. Nolan, D. J. et al. Dev. Cell 26, 204–219 (2013).

    CAS  Article  Google Scholar 

  11. Rasmussen, J. C. et al. J. Vasc. Surg. Cases 1, 201–204 (2015).

    Article  Google Scholar 

  12. Rasmussen, J. C., Fife, C. E. & Sevick-Muraca, E. M. Lymphat. Res. Biol. 13, 195–201 (2015).

    Article  Google Scholar 

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Correspondence to Ayuko Hoshino or David Lyden.

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Hoshino, A., Lyden, D. Lymphatic detours for cancer. Nature 546, 609–610 (2017). https://doi.org/10.1038/546609a

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