Research Highlights | Published:


'Jet lag' increases mouse cancer risk

Nature volume 540, page 10 (01 December 2016) | Download Citation


Mice with simulated jet lag have an increased risk of developing liver cancer.

Sleeping out of step with the day–night cycle has been linked to various health disorders in humans. David Moore, Loning Fu and their colleagues at Baylor College of Medicine in Houston, Texas, subjected mice to disrupted day–night cycles using artificial lights to simulate chronic jet lag. Compared with mice under steady 24-hour light–dark cycles, jet-lagged animals had impaired liver metabolism and were more prone to developing fatty liver disease and liver cancer.

Much of the disrupted metabolism was linked to excessive accumulation of bile acid in the liver and altered activities of the nuclear receptors FXR and CAR, which might be targets for preventing liver cancer in future.

Cancer Cell (2016)

About this article

Publication history





    By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

    Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing