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Structural biology

Moulding the ribosome

Production of the cell's translational apparatus, the ribosome, requires the orchestrated function of hundreds of proteins. A structure of its earliest precursor yields unprecedented insight into ribosome formation.

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Figure 1: Maturation of the 90S pre-ribosome.

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References

  1. Kornprobst, M. et al. Cell 166, 380–393 (2016).

    Article  CAS  Google Scholar 

  2. Kühlbrandt, W. eLife 3, e03678 (2014).

    Article  Google Scholar 

  3. Weinberg, R. A., Loening, U., Willems, M. & Penman, S. Proc. Natl Acad. Sci. USA 58, 1088–1095 (1967).

    Article  ADS  CAS  Google Scholar 

  4. Warner, J. R. & Soeiro, R. Proc. Natl Acad. Sci. USA 58, 1984–1990 (1967).

    Article  ADS  CAS  Google Scholar 

  5. Kumar, A. & Warner, J. R. J. Mol. Biol. 63, 233–246 (1972).

    Article  CAS  Google Scholar 

  6. Woolford, J. L. & Baserga, S. J. Genetics 195, 643–681 (2013).

    Article  CAS  Google Scholar 

  7. Henras, A. K., Plisson-Chastang, C., O'Donohue, M.-F., Chakraborty, A. & Gleizes, P.-E. Wiley Interdisc. Rev. RNA 6, 225–242 (2014).

    Article  Google Scholar 

  8. Chaker-Margot, M., Hunziker, M., Barandun, J., Dill, B. D. & Klinge, S. Nature Struct. Mol. Biol. 22, 920–923 (2015).

    Article  CAS  Google Scholar 

  9. Hartl, F. U., Bracher, A. & Hayer-Hartl, M. Nature 475, 324–332 (2011).

    Article  CAS  Google Scholar 

  10. Dragon, F. et al. Nature 417, 967–970 (2002).

    Article  ADS  CAS  Google Scholar 

  11. Dutca, L. M., Gallagher, J. E. G. & Baserga, S. J. Nucleic Acids Res. 39, 5164–5180 (2011).

    Article  CAS  Google Scholar 

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Correspondence to Marlene Oeffinger.

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Oeffinger, M. Moulding the ribosome. Nature 537, 38–40 (2016). https://doi.org/10.1038/537038a

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