Three studies reveal that augmentation of a signalling pathway involving the growth factor neuregulin 1 and its receptor protein ERBB2 can promote the generation of muscle cells in zebrafish, mice and infant heart tissue.
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Catheter-based Intramyocardial Injection of FGF1 or NRG1-loaded MPs Improves Cardiac Function in a Preclinical Model of Ischemia-Reperfusion
Scientific Reports Open Access 17 May 2016
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Soonpaa, M. H. & Field, L. J. Circ. Res. 83, 15–26 (1998).
Bergmann, O. et al. Science 324, 98–102 (2009).
Senyo, S. E. et al. Nature 493, 433–436 (2013).
Gemberling, M., Karra, R., Dickson, A. L. & Poss, K. D. eLIFE 4, e05871 (2015).
D'Uva, G. et al. Nature Cell Biol. http://dx.doi.org/10.1038/ncb3149 (2015).
Polizzotti, B. D. et al. Sci. Transl. Med. http://dx.doi.org/10.1126/scitranslmed.aaa5171 (2015).
Poss, K. D., Wilson, L. G. & Keating, M. T. Science 298, 2188–2190 (2002).
Cote, G. M., Sawyer, D. B. & Chabner, B. A. N. Engl. J. Med. 367, 2150–2153 (2012).
Bersell, K., Arab, S., Haring, B. & Kühn, B. Cell 138, 257–270 (2009).
Reuter, S., Soonpaa, M. H., Firulli, A. B., Chang, A. N. & Field, L. J. PLoS ONE 9, e115871 (2014).
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Yutzey, K. Neuregulin 1 makes heart muscle. Nature 520, 445–446 (2015). https://doi.org/10.1038/520445a