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Synthetic biology

Toehold gene switches make big footprints

The development of RNA-based devices called toehold switches that regulate translation might usher in an era in which protein production can be linked to almost any RNA input and provide precise, low-cost diagnostics.

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Figure 1: The design of toehold switches.

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Correspondence to Martin Fussenegger.

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Ausländer, S., Fussenegger, M. Toehold gene switches make big footprints. Nature 516, 333–334 (2014). https://doi.org/10.1038/516333a

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