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Genomics

Mice in the ENCODE spotlight

Nature volume 515, pages 346–347 (2014)Cite this article

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Following on from affiliated projects in humans and model invertebrates, the Mouse ENCODE Project presents comprehensive data sets on genome regulation in this key mammalian model. See Articles p.355, p.365, p.371 & Letter p.402

The mouse genome was sequenced in 2002 as a primary model in which to study gene function and human diseases and to develop drugs1. This was followed by maps of transcribed messenger RNA molecules and of long, non-protein-coding RNAs, which facilitated such experiments and analysis2. Yet although 17 mouse strains have been sequenced3, genome function and regulation cannot be understood by sequence analysis alone. Now, in four papers published in this issue4,5,6,7, the Mouse ENCODE Consortium presents data sets that dramatically enhance our understanding of the regulation of the mouse genome, and of the similarities and differences compared with the human genome.

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Figure 1: Transcription-factor binding in mice and humans.

References

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Authors and Affiliations

  1. Division of Genomic Technologies, Piero Carninci is at the RIKEN Center for Life Science Technologies, RIKEN Yokohama Campus, Yokohama, Kanagawa 230-0045, Japan.,

    Piero Carninci

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  1. Piero Carninci
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Correspondence to Piero Carninci.

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Carninci, P. Mice in the ENCODE spotlight. Nature 515, 346–347 (2014). https://doi.org/10.1038/515346a

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