Neuroscience

Cell transplants stem seizures

    Stem-cell therapy can reduce seizures in epileptic mice.

    Some forms of epilepsy are thought to be caused by dysfunctional cells in the hippocampus region of the brain. The affected cells, called inhibitory interneurons, help to regulate neural circuits. Robert Hunt, Scott Baraban and their colleagues at the University of California, San Francisco, harvested progenitors of inhibitory neurons from embryonic mice and injected them into the hippocampi of epileptic adult mice.

    In the brain, the cells matured into functioning inhibitory interneurons. Mice that received cell transplants had many fewer seizures than untreated mice. The transplants also reversed some behavioural problems that epileptic mice often develop, such as hyperactivity and poor spatial learning.

    Nature Neurosci. http://dx.doi.org/10.1038/nn.3392 (2013)

    Rights and permissions

    Reprints and Permissions

    About this article

    Cite this article

    Cell transplants stem seizures. Nature 497, 290 (2013). https://doi.org/10.1038/497290b

    Download citation

    Comments

    By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.