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Evolutionary biology

Insects converge on resistance

In a remarkable example of convergent evolution, insect species spanning 300 million years of divergence have evolved identical single-amino-acid substitutions that confer resistance to plant cardenolide toxins.

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Figure 1: Hierarchy of adaptation.


  1. Ehrlich, P. R. & Raven, P. H. Evolution 18, 586–603 (1965).

    Article  Google Scholar 

  2. Fraenkel, G. Science 129, 1466–1470 (1959).

    CAS  Article  ADS  Google Scholar 

  3. Dethier, V. G. Evolution 8, 33–54 (1954).

    Article  Google Scholar 

  4. Winde, I. & Wittstock, U. Phytochemistry 72, 1566–1575 (2011).

    CAS  Article  Google Scholar 

  5. Rasmann, S. & Agrawal, A. A. Ecol. Lett. 14, 476–483 (2011).

    Article  Google Scholar 

  6. Dobler, S., Dalla, S., Wagschal, V. & Agrawal, A. A. Proc. Natl Acad. Sci. USA 109, 13040–13045 (2012).

    CAS  Article  ADS  Google Scholar 

  7. Bernays, E. A. BioScience 48, 35–44 (1998).

    Article  Google Scholar 

  8. McDonald, J. H. & Kreitman, M. Nature 351, 652–654 (1991).

    CAS  Article  ADS  Google Scholar 

  9. Aardema, M. L., Zhen, Y. & Andolfatto, P. Mol. Ecol. 21, 340–349 (2012).

    CAS  Article  Google Scholar 

  10. Fink, L. S. & Brower, L. P. Nature 291, 67–70 (1981).

    CAS  Article  ADS  Google Scholar 

  11. Dean, A. M. & Thornton, J. W. Nature Rev. Genet. 8, 675–688 (2007).

    CAS  Article  Google Scholar 

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Correspondence to Noah K. Whiteman or Kailen A. Mooney.

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Whiteman, N., Mooney, K. Insects converge on resistance. Nature 489, 376–377 (2012).

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