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Organic synthesis

A biochemical messenger made easily

Nature volume 489, pages 214–215 (2012)Cite this article

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Biochemicals known as prostaglandins are challenging targets for synthetic organic chemistry. Yet by channelling the reactivity of a simple reactant, a powerful synthesis of one such compound has been achieved. See Letter p.278

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Figure 1: Landmark syntheses of prostaglandin F2α (PGF2α).
Figure 2: A concise synthesis of PGF2α.

References

  1. Bergström, S., Carlson, L. A. & Weeks, J. R. Pharmacol. Rev. 20, 1–48 (1968).

    PubMed  Google Scholar 

  2. Bindra, J. S. & Bindra, R. Prostaglandin Synthesis (Academic, 1977).

    Google Scholar 

  3. Mitra, A. The Synthesis of Prostaglandins (Wiley-Interscience, 1977).

    Google Scholar 

  4. Coulthard, G., Erb, W. & Aggarwal, V. K. Nature 489, 278–281 (2012).

    Article  ADS  CAS  Google Scholar 

  5. Corey, E. J., Weinshenker, N. M., Schaaf, T. K. & Huber, W. J. Am. Chem. Soc. 91, 5675–5677 (1969).

    Article  CAS  Google Scholar 

  6. Woodward, R. B. et al. J. Am. Chem. Soc. 95, 6853–6855 (1973).

    Article  CAS  Google Scholar 

  7. Stork, G., Takahashi, T., Kawamoto, I. & Suzuki, T. J. Am. Chem. Soc. 100, 8272–8373 (1978).

    Article  CAS  Google Scholar 

  8. Stork, G., Sher, P. M. & Chen, H.-L. J. Am. Chem. Soc. 108, 6384–6385 (1986).

    Article  CAS  Google Scholar 

  9. Suzuki, M., Yanagisawa, A. & Noyori, R. J. Am. Chem. Soc. 110, 4718–4726 (1988).

    Article  CAS  Google Scholar 

  10. List, B., Lerner, R. A. & Barbas, C. F. III J. Am. Chem. Soc. 122, 2395–2396 (2000).

    Article  CAS  Google Scholar 

  11. Northrup, A. B. & MacMillan, D. W. C. Science 305, 1752–1755 (2004).

    Article  ADS  CAS  Google Scholar 

  12. Mukherjee, S., Yang, J. W., Hoffmann, S. & List, B. Chem. Rev. 107, 5471–5569 (2007).

    Article  CAS  Google Scholar 

  13. Corey, E. J. et al. J. Am. Chem. Soc. 100, 8031–8034 (1978).

    Article  CAS  Google Scholar 

  14. Robinson, R. J. Chem. Soc. 762–768 (1917).

Download references

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  1. Erik J. Sorensen is in the Department of Chemistry, Princeton University, Princeton, New Jersey 08544, USA.,

    Erik J. Sorensen

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  1. Erik J. Sorensen
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Correspondence to Erik J. Sorensen.

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Sorensen, E. A biochemical messenger made easily. Nature 489, 214–215 (2012). https://doi.org/10.1038/489214a

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