Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Exploiting collateral damage

Some mutations in tumour cells play no part in causing cancer, but they generate cellular weak spots that may allow tumour cells to be selectively killed by drugs. See Article p.337

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Therapy in the passenger seat.


  1. Muller, F. L. et al. Nature 488, 337–342 (2012).

    Article  CAS  ADS  Google Scholar 

  2. Sellers, W. R. Cell 147, 26–31 (2011).

    Article  CAS  Google Scholar 

  3. Workman, P. & de Bono, J. Curr. Opin. Pharmacol. 8, 359–362 (2008).

    Article  CAS  Google Scholar 

  4. Stratton, M. R., Campbell, P. J. & Futreal, P. A. Nature 458, 719–724 (2009).

    Article  CAS  ADS  Google Scholar 

  5. Vavouri, T., Semple, J. I. & Lehner, B. Trends Genet. 24, 485–488 (2008).

    Article  CAS  Google Scholar 

  6. Kafri, R., Bar-Even, A. & Pilpel, Y. Nature Genet. 37, 295–299 (2005).

    Article  CAS  Google Scholar 

  7. Burga, A., Casanueva, M. O. & Lehner, B. Nature 480, 250–253 (2011).

    Article  CAS  ADS  Google Scholar 

  8. Lehner, B. Trends Genet. 27, 323–331 (2011).

    Article  CAS  Google Scholar 

  9. Hartwell, L. H., Szankasi, P., Roberts, C. J., Murray, A. W. & Friend, S. H. Science 278, 1064–1068 (1997).

    Article  CAS  ADS  Google Scholar 

  10. Chan, D. A. & Giaccia, A. J. Nature Rev. Drug Discov. 10, 351–364 (2011).

    Article  CAS  Google Scholar 

  11. Nijhawan, D. et al. Cell (2012).

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Ben Lehner.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Lehner, B., Park, S. Exploiting collateral damage. Nature 488, 284–285 (2012).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer