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Biochemistry

DNA replication caught in the act

By freezing a DNA polymerase enzyme at several points along its reaction pathway, a sequence of X-ray crystal structures has been obtained, showing how the enzyme replicates DNA and revealing surprising mechanistic details. See Article p.196

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Figure 1: Snapshots of DNA replication.

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Correspondence to Kenneth A. Johnson.

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The author is president of KinTek Corporation, which manufactures and sells equipment and software for enzyme kinetic analysis.

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Johnson, K. DNA replication caught in the act. Nature 487, 177–178 (2012). https://doi.org/10.1038/487177a

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