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Protein engineering

Tighter ties that bind

A stepwise process of mutation and structural analysis has modulated a flexible binding interface of an immune-cell signalling protein, interleukin-2, and generated mutant proteins with enhanced anticancer activity. See Article p.529

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Figure 1: Signalling superpowers.

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Correspondence to Eric T. Boder.

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Boder, E. Tighter ties that bind. Nature 484, 463–464 (2012). https://doi.org/10.1038/484463a

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