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Organic chemistry

Stabilizers cause instability

Any chemist will tell you that amide compounds are renowned for their stability, yet a family of amides has been discovered that is surprisingly unstable. The cause of this phenomenon is even more surprising.

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Figure 1: Amide reactivity.

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Correspondence to Jonathan Clayden.

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Clayden, J. Stabilizers cause instability. Nature 481, 274–275 (2012). https://doi.org/10.1038/481274a

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