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Sacrifice for survival

Cancer cells ignore oxygen availability, opting for less efficient, anaerobic ways of generating energy. The wisdom behind this choice seems to be in preventing the accumulation of reactive oxygen species, and so oxidative damage.

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Figure 1: Restructuring cellular metabolism.


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Correspondence to Nana-Maria Grüning or Markus Ralser.

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Grüning, NM., Ralser, M. Sacrifice for survival. Nature 480, 190–191 (2011).

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