Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Muscular dystrophy

A hidden ancestral legacy trumped

A previously unsuspected genetic mechanism underlies a type of muscular dystrophy common in Japan. A therapeutic approach based on this finding and tested in mice has come up with encouraging results. See Letter p.127

This is a preview of subscription content

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: Abnormal splicing of the fukutin gene.

References

  1. 1

    Fukuyama, Y., Osawa, M. & Suzuki, H. Brain Dev. 3, 1–29 (1981).

    CAS  Article  Google Scholar 

  2. 2

    Taniguchi-Ikeda, M. et al. Nature 478, 127–131 (2011).

    CAS  Article  ADS  Google Scholar 

  3. 3

    Toda, T. & Kobayashi, K. J. Mol. Med. 77, 816–823 (1999).

    CAS  Article  Google Scholar 

  4. 4

    Xing, J. et al. Genome Res. 19, 1516–1526 (2009).

    CAS  Article  Google Scholar 

  5. 5

    Hayashi, Y. K. et al. Neurology 57, 115–121 (2001).

    CAS  Article  Google Scholar 

  6. 6

    Michele, D. E. et al. Nature 418, 417–422 (2002).

    CAS  Article  ADS  Google Scholar 

  7. 7

    Kobayashi, K. et al. Nature 394, 388–392 (1998).

    CAS  Article  ADS  Google Scholar 

  8. 8

    Hancks, D. C., Ewing, A. D., Chen, J. E., Tokunaga, K. & Kazazian, H. H. Jr Genome Res. 19, 1983–1991 (2009).

    CAS  Article  Google Scholar 

  9. 9

    Dominski, Z. & Kole, R. Proc. Natl Acad. Sci. USA 90, 8673–8677 (1993).

    CAS  Article  ADS  Google Scholar 

  10. 10

    Muntoni, F. & Wood, M. J. A. Nature Rev. Drug Discov. 10, 621–637 (2011).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Charles Thornton.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Nakamori, M., Thornton, C. A hidden ancestral legacy trumped. Nature 478, 46–47 (2011). https://doi.org/10.1038/478046a

Download citation

Search

Quick links