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Molecular medicine

Defence against oxidative damage

Macular degeneration is a leading cause of blindness in the elderly in the developed world. Hope for prevention and treatment comes from the discovery of a protective mechanism against oxidative damage to the eye. See Letter p.76

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Figure 1: Mechanisms at work in age-related macular degeneration.


  1. Takeda, A. et al. Nature 460, 225–230 (2009).

    Article  CAS  ADS  Google Scholar 

  2. Weismann, D. et al. Nature 478, 76–81 (2011).

    Article  CAS  ADS  Google Scholar 

  3. Telander, D. G. Semin. Ophthalmol. 26, 192–197 (2011).

    Article  Google Scholar 

  4. Crabb, J. W. et al. Proc. Natl Acad. Sci. USA 99, 14682–14687 (2002).

    Article  CAS  ADS  Google Scholar 

  5. Klein, R. J. et al. Science 308, 385–389 (2005).

    Article  CAS  ADS  Google Scholar 

  6. Haines, J. L. et al. Science 308, 419–421 (2005).

    Article  CAS  ADS  Google Scholar 

  7. Edwards, A. O. et al. Science 308, 421–424 (2005).

    Article  CAS  ADS  Google Scholar 

  8. Miller, Y. I. et al. Circ. Res. 108, 235–248 (2011).

    Article  CAS  Google Scholar 

  9. Suzuki, M. et al. Mol. Vision 13, 772–778 (2007).

    CAS  Google Scholar 

  10. Hollyfield, J. G. et al. Nature Med. 14, 194–198 (2008).

    Article  CAS  Google Scholar 

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Correspondence to Victor L. Perez.

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Cruz-Guilloty, F., Perez, V. Defence against oxidative damage. Nature 478, 42–43 (2011).

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