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Molecular evolution

Hidden diversity sparks adaptation

Although some genetic mutations have clear effects, others have been considered neutral and inconsequential. Such cryptic mutations can nonetheless facilitate adaptation to new environments. See Letter p.92

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Figure 1: Role of cryptic genetic variation in adaptation.

References

  1. Hayden, E. J., Ferrada, E. & Wagner, A. Nature 474, 92–95 (2011).

    Article  CAS  Google Scholar 

  2. Elena, S. F. & Lenski, R. E. Nature Rev. Genet. 4, 457–469 (2003).

    Article  CAS  Google Scholar 

  3. Blount, Z. D., Borland, C. Z. & Lenski, R. E. Proc. Natl Acad. Sci. USA 105, 7899–7906 (2008).

    Article  ADS  CAS  Google Scholar 

  4. Woods, R. J. et al. Science 331, 1433–1436 (2011).

    Article  ADS  CAS  Google Scholar 

  5. Wagner, A. Robustness and Evolvability in Living Systems (Princeton Univ. Press, 2005).

    Google Scholar 

  6. Hermisson, J. & Wagner, G. P. Genetics 168, 2271–2284 (2004).

    Article  Google Scholar 

  7. Draghi, J. A., Parsons, T. L., Wagner, G. P. & Plotkin, J. B. Nature 463, 353–355 (2010).

    Article  ADS  CAS  Google Scholar 

  8. Masel, J. & Trotter, M. V. Trends Genet. 26, 406–414 (2010).

    Article  CAS  Google Scholar 

  9. Schlichting, C. D. Ann. NY Acad. Sci. 1133, 187–203 (2008).

    Article  ADS  Google Scholar 

  10. Jarosz, D. F. & Lindquist, S. Science 330, 1820–1824 (2010).

    Article  ADS  CAS  Google Scholar 

  11. Provine, W. B. Sewall Wright and Evolutionary Biology (Chicago Univ. Press, 1986).

    Google Scholar 

  12. Bloom, J. D., Labthavikul, S. T., Otey, C. R. & Arnold, F. H. Proc. Natl Acad. Sci. USA 103, 5869–5874 (2006).

    Article  ADS  CAS  Google Scholar 

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Correspondence to Joshua B. Plotkin.

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Draghi, J., Plotkin, J. Hidden diversity sparks adaptation. Nature 474, 45–46 (2011). https://doi.org/10.1038/474045a

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