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Cancer

Macrophages limit chemotherapy

A major hurdle to successful cancer treatment is tumour resistance to chemotherapy. White blood cells called macrophages often infiltrate tumours in large numbers, and now appear to promote tumour chemoresistance.

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Figure 1: Macrophages promote tumour chemoresistance.

References

  1. de Visser, K. E., Eichten, A., Coussens, L. M. Nature Rev. Cancer 6, 24–37 (2006).

    CAS  Article  Google Scholar 

  2. Mellor, A. L. & Munn, D. H. Nature Rev. Immunol. 8, 74–80 (2008).

    CAS  Article  Google Scholar 

  3. Lewis, C. E. & Pollard, J. W. Cancer Res. 66, 605–612 (2006).

    CAS  Article  Google Scholar 

  4. DeNardo, D. G. et al. Cancer Discov. 10.1158/2159-8274.CD-10-0028 (2011).

  5. DeNardo, D. G., Andreu, P. & Coussens, L. M. Cancer Metastasis Rev. 29, 309–316 (2010).

    Article  Google Scholar 

  6. Andreu, P. et al. Cancer Cell 17, 121–134 (2010).

    CAS  Article  Google Scholar 

  7. Bingle, L., Brown, N. J. & Lewis, C. E. J. Pathol. 196, 254–265 (2002).

    CAS  Article  Google Scholar 

  8. Galon, J. et al. Science 313, 1960–1964 (2006).

    ADS  CAS  Article  Google Scholar 

  9. Paulus, P., Stanley, E. R., Schäfer, R., Abraham, D. & Aharinejad, S. Cancer Res. 66, 4349–4356 (2006).

    CAS  Article  Google Scholar 

  10. Pucci, F. et al. Blood 114, 901–914 (2009).

    CAS  Article  Google Scholar 

  11. Stockmann, C. et al. Nature 456, 814–818 (2008).

    ADS  CAS  Article  Google Scholar 

  12. Rolny, C. et al. Cancer Cell 19, 31–44 (2011).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Michele De Palma or Claire E. Lewis.

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De Palma, M., Lewis, C. Macrophages limit chemotherapy. Nature 472, 303–304 (2011). https://doi.org/10.1038/472303a

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