Immunology

Context is key in the gut

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The vitamin-A metabolite retinoic acid normally favours immune tolerance in the gut. But in coeliac disease — an intestinal inflammatory disorder due to adverse reactivity to a dietary protein — it may do just the opposite. See Letter p.220

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Figure 1: Dual and competing roles of retinoic acid in mucosal T-cell responses.

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Correspondence to Craig L. Maynard or Casey T. Weaver.

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Maynard, C., Weaver, C. Context is key in the gut. Nature 471, 169–170 (2011) doi:10.1038/471169a

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