Watson–Crick base pairs underpin the DNA double helix. Evidence of transient changes in base-pairing geometry highlights the fact that the information held in DNA's linear sequence is stored in three dimensions. See Article p.498
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References
Nikolova, E. N. et al. Nature 470, 498–502 (2011).
Parker, S. C. J., Hansen, L., Abaan, H. O., Tullius, T. D. & Margulies, E. H. Science 324, 389–392 (2009).
Rohs, R. et al. Nature 461, 1248–1253 (2009).
Watson, J. D. & Crick, F. H. C. Nature 171, 737–738 (1953).
Hoogsteen, K. Acta Crystallogr. 16, 907–916 (1963).
Palmer, A. G. & Massi, F. Chem. Rev. 106, 1700–1719 (2006).
Aishima, J. et al. Nucleic Acids Res. 30, 5244–5252 (2002).
Nair, D. T., Johnson, R. E., Prakash, S., Prakash, L. & Aggarwal, A. K. Nature 430, 377–380 (2004).
Kitayner, M. et al. Nature Struct. Mol. Biol. 17, 423–429 (2010).
Rohs, R. et al. Annu. Rev. Biochem. 79, 233–269 (2010).
Chen, Y., Dey, R. & Chen, L. Structure 18, 246–256 (2010).
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Honig, B., Rohs, R. Flipping Watson and Crick. Nature 470, 472–473 (2011). https://doi.org/10.1038/470472a
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DOI: https://doi.org/10.1038/470472a
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