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Flipping Watson and Crick


Watson–Crick base pairs underpin the DNA double helix. Evidence of transient changes in base-pairing geometry highlights the fact that the information held in DNA's linear sequence is stored in three dimensions. See Article p.498

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Figure 1: Hoogsteen and Watson–Crick base pairing.


  1. Nikolova, E. N. et al. Nature 470, 498–502 (2011).

    CAS  Article  ADS  Google Scholar 

  2. Parker, S. C. J., Hansen, L., Abaan, H. O., Tullius, T. D. & Margulies, E. H. Science 324, 389–392 (2009).

    CAS  Article  ADS  Google Scholar 

  3. Rohs, R. et al. Nature 461, 1248–1253 (2009).

    CAS  Article  ADS  Google Scholar 

  4. Watson, J. D. & Crick, F. H. C. Nature 171, 737–738 (1953).

    CAS  Article  ADS  Google Scholar 

  5. Hoogsteen, K. Acta Crystallogr. 16, 907–916 (1963).

    CAS  Article  Google Scholar 

  6. Palmer, A. G. & Massi, F. Chem. Rev. 106, 1700–1719 (2006).

    CAS  Article  Google Scholar 

  7. Aishima, J. et al. Nucleic Acids Res. 30, 5244–5252 (2002).

    CAS  Article  Google Scholar 

  8. Nair, D. T., Johnson, R. E., Prakash, S., Prakash, L. & Aggarwal, A. K. Nature 430, 377–380 (2004).

    CAS  Article  ADS  Google Scholar 

  9. Kitayner, M. et al. Nature Struct. Mol. Biol. 17, 423–429 (2010).

    CAS  Article  Google Scholar 

  10. Rohs, R. et al. Annu. Rev. Biochem. 79, 233–269 (2010).

    CAS  Article  Google Scholar 

  11. Chen, Y., Dey, R. & Chen, L. Structure 18, 246–256 (2010).

    CAS  Article  Google Scholar 

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Correspondence to Barry Honig or Remo Rohs.

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Honig, B., Rohs, R. Flipping Watson and Crick. Nature 470, 472–473 (2011).

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