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Tumour stem cells switch sides

Tumour stem cells are proposed to be the source of tumour cells. It now emerges that they also give rise to the endothelial cells that line the tumour vasculature, mediating tumour growth and metastasis. See Letters p.824 & p.829

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Figure 1: Tumour stem-like cells are multipotent.


  1. Hanahan, D. & Folkman, J. Cell 86, 353–364 (1996).

    CAS  Google Scholar 

  2. Wang, R. et al. Nature 468, 829–833 (2010).

    CAS  Google Scholar 

  3. Ricci-Vitiani, L. et al. Nature 468, 824–828 (2010).

    CAS  Google Scholar 

  4. Hendrix, M. J. C., Seftor, E. A., Hess, A. R. & Seftor, R. E. B. Nature Rev. Cancer 3, 411–421 (2003).

    CAS  Google Scholar 

  5. El Hallani, S. et al. Brain 133, 973–982 (2010).

    Google Scholar 

  6. Lathia, J. D., Venere, M., Rao, M. S. & Rich, J. N. Stem Cell Rev. Rep. doi:10.1007/s12105-010-9194-6 (2010).

  7. Dong, J. et al. Stem Cell Rev. Rep. doi:10.1007/s12105-010-9169-7 (2010).

  8. Streubel, B. et al. N. Engl. J. Med. 351, 250–259 (2004).

    CAS  Google Scholar 

  9. Pezzolo, A. et al. J. Clin. Oncol. 25, 376–383 (2007).

    CAS  Google Scholar 

  10. Hida, K. et al. Cancer Res. 64, 8249–8255 (2004).

    CAS  Google Scholar 

  11. Akino, T. et al. Am. J. Pathol. 175, 2657–2667 (2009).

    CAS  Google Scholar 

  12. Taylor, S. M. et al. Blood 116, 3108–3117 (2010).

    CAS  Google Scholar 

  13. Dudley, A. C. et al. Cancer Cell 14, 201–211 (2008).

    CAS  Google Scholar 

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Bautch, V. Tumour stem cells switch sides. Nature 468, 770–771 (2010).

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