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Analytical biochemistry

Weighing up protein folding

Labelling molecules by fast oxidation allows mass spectrometry to study protein folding at submillisecond time resolution. The method also brings a wealth of structural information about protein folding within reach.

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Figure 1: Improving the time resolution of mass spectrometry in protein-folding studies.

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Gruebele, M. Weighing up protein folding. Nature 468, 640–641 (2010). https://doi.org/10.1038/468640a

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