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HIV

Antibodies with a split personality

Spikes on the surface of HIV to which antibodies can bind are sparse. One of nature's solutions is to sometimes produce antibodies that bind tightly to a spike with one arm and grab another structure with the other arm. See Letter p.591

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Figure 1: Dealing with the problem of epitope shortage.

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Plückthun, A. Antibodies with a split personality. Nature 467, 537–538 (2010). https://doi.org/10.1038/467537a

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