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Alzheimer's disease

Selectively tuning γ-secretase

Presenilin proteins have a major role in normal cellular processes, but some contribute to disease, for example through the formation of amyloid-β. The way in which these different roles are regulated is now becoming clearer.

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Figure 1: Complexities of presenilin-dependent cleavage.

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St George-Hyslop, P., Schmitt-Ulms, G. Selectively tuning γ-secretase. Nature 467, 36–37 (2010). https://doi.org/10.1038/467036a

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