Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Methylation matters

Genome-wide maps of methylated cytosine bases at single-base-pair resolution in human cells reveal distinct differences between cell types. These maps provide a starting point to decode the function of this enigmatic mark.

Your institute does not have access to this article

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: DNA methylation patterns differ between stem cells and differentiated cells1.


  1. Lister, R. et al. Nature 462, 315–322 (2009).

    ADS  CAS  Article  Google Scholar 

  2. Meissner, A. et al. Nature 454, 766–770 (2008).

    ADS  CAS  Article  Google Scholar 

  3. Eckhardt, F. et al. Nature Genet. 38, 1378–1385 (2006).

    CAS  Article  Google Scholar 

  4. Frommer, M. et al. Proc. Natl Acad. Sci. USA 89, 1827–1831 (1992).

    ADS  CAS  Article  Google Scholar 

  5. Ramsahoye, B. H. et al. Proc. Natl Acad. Sci. USA 97, 5237–5242 (2000).

    ADS  CAS  Article  Google Scholar 

  6. Zhang, X. et al. Cell 126, 1189–1201 (2006).

    CAS  Article  Google Scholar 

  7. Zilberman, D. et al. Nature Genet. 39, 61–69 (2007).

    CAS  Article  Google Scholar 

  8. Mohn, F. & Schübeler, D. Trends Genet. 25, 129–136 (2009).

    CAS  Article  Google Scholar 

  9. Jones, P. A. et al. Nature 454, 711–715 (2008).

    ADS  CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

Schübeler, D. Methylation matters. Nature 462, 296–297 (2009).

Download citation

  • Published:

  • Issue Date:

  • DOI:

Further reading


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing