Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Genetics

Crossover control in two steps

During meiotic cell division, chromosome pairs exchange genetic material in a tightly controlled crossover process. Higher-order chromosome structure may regulate this genetic reshuffling at two distinct stages of meiosis.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Crossover formation and control.

References

  1. Mets, D. G. & Meyer, B. J. Cell 139, 73–86 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Pâques, F. & Haber, J. E. Microbiol. Mol. Biol. Rev. 63, 349–404 (1999).

    PubMed  PubMed Central  Google Scholar 

  3. Martinez-Perez, E. & Colaiácovo, M. P. Curr. Opin. Genet. Dev. 19, 105–112 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Kauppi, L., Jeffreys, A. J. & Keeney, S. Nature Rev. Genet. 5, 413–424 (2004).

    Article  CAS  PubMed  Google Scholar 

  5. Petes, T. D. Nature Rev. Genet. 2, 360–369 (2001).

    Article  CAS  PubMed  Google Scholar 

  6. Jones, G. H. Symp. Soc. Exp. Biol. 38, 293–320 (1984).

    CAS  PubMed  Google Scholar 

  7. Muller, H. J. Am. Nat. 50, 193–221 (1916).

    Article  Google Scholar 

  8. Martini, E., Diaz, R. L., Hunter, N. & Keeney, S. Cell 126, 285–295 (2006).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Meneely, P. M., Farago, A. F. & Kauffman, T. M. Genetics 162, 1169–1177 (2002).

    CAS  PubMed  PubMed Central  Google Scholar 

  10. Tsai, C. J. et al. Genes Dev. 22, 194–211 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Csankovszki, G. et al. Curr. Biol. 19, 9–19 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Chan, R. C., Severson, A. F. & Meyer, B. J. J. Cell Biol. 167, 613–625 (2004).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Hagstrom, K. A., Holmes, V. F., Cozzarelli, N. R. & Meyer, B. J. Genes Dev. 16, 729–742 (2002).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Zickler, D. & Kleckner, N. Annu. Rev. Genet. 33, 603–754 (1999).

    Article  CAS  PubMed  Google Scholar 

  15. Hagstrom, K. A. & Meyer, B. J. Nature Rev. Genet. 4, 520–534 (2003).

    Article  CAS  PubMed  Google Scholar 

  16. Blat, Y., Protacio, R. U., Hunter, N. & Kleckner, N. Cell 111, 791–802 (2002).

    Article  CAS  PubMed  Google Scholar 

  17. Kleckner, N. et al. Proc. Natl Acad. Sci. USA 101, 12592–12597 (2004).

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Tzur, Y., Colaiácovo, M. Crossover control in two steps. Nature 462, 46–47 (2009). https://doi.org/10.1038/462046a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/462046a

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing