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A tumour gene's fatal flaws

Mutations in RAS genes are common in human tumours, but RAS has proved impossible to target with drugs. Its associated NF-κB signalling pathway, however, may turn out to be this tumour gene's Achilles heel.

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Figure 1: The RAS and NF-κB signalling pathways.


  1. Barbie, D. A. et al. Nature 462, 108–112 (2009).

    Article  ADS  CAS  Google Scholar 

  2. Meylan, E. et al. Nature 462, 104–107 (2009).

    Article  ADS  CAS  Google Scholar 

  3. Luo, J. et al. Cell 137, 835–848 (2009).

    Article  CAS  Google Scholar 

  4. Scholl, C. et al. Cell 137, 821–834 (2009).

    Article  CAS  Google Scholar 

  5. Hacker, H. & Karin, M. Sci. STKE 2006, re13 (2006).

  6. Baud, V. & Karin, M. Nature Rev. Drug Discov. 8, 33–40 (2009).

    Article  CAS  Google Scholar 

  7. Mayo, M. W. et al. Science 278, 1812–1815 (1997).

    Article  ADS  CAS  Google Scholar 

  8. Chien, Y. et al. Cell 127, 157–170 (2006).

    Article  CAS  Google Scholar 

  9. Engelman, J. A. et al. Nature Med. 14, 1351–1356 (2008).

    Article  CAS  Google Scholar 

  10. Dajee, M. et al. Nature 421, 639–643 (2003).

    Article  ADS  CAS  Google Scholar 

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Downward, J. A tumour gene's fatal flaws. Nature 462, 44–45 (2009).

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