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Structural biology

Tracing Argonaute binding

Argonaute proteins inhibit gene expression by binding to messenger RNA via a small nucleic-acid guide. Structures of the Argonaute complex bound to target RNA reveal snapshots of a silencing machine at work.

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Figure 1: The Argonaute silencing complex at work.


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Bouasker, S., Simard, M. Tracing Argonaute binding. Nature 461, 743–744 (2009).

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