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Drug discovery

Propping up a destructive regime

Nature volume 461, pages 599–600 (2009)Cite this article

The Wnt signalling pathway balances the opposing activities of two proteins to transmit signals within cells. An inhibitor that stabilizes one of these proteins reveals a new target for anticancer drug development.

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Figure 1: The Wnt-signalling seesaw.

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Authors and Affiliations

  1. Randall T. Peterson is at the Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA, and at the Broad Institute, Cambridge, Massachusetts. peterson@cvrc.mgh.harvard.edu ,

    Randall T. Peterson

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  1. Randall T. Peterson
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Peterson, R. Propping up a destructive regime. Nature 461, 599–600 (2009). https://doi.org/10.1038/461599a

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