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Developmental biology

A cellular view of regeneration

How the salamander regrows an entire limb after injury has flummoxed the wisest of scientists. A closer look at the cells involved in limb regeneration shows that remembering past origins may be crucial for this feat.

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Figure 1: Cell-tracking techniques used by Kragl and colleagues1.
Figure 2: Lineages are respected during axolotl limb regeneration.


  1. Kragl, M. et al. Nature 460, 60–65 (2009).

    Article  ADS  CAS  Google Scholar 

  2. Birnbaum, K. D. & Sánchez Alvarado, A. Cell 132, 697–710 (2008).

    Article  CAS  Google Scholar 

  3. Grogg, M. W. et al. Nature 438, 858–862 (2005).

    Article  ADS  CAS  Google Scholar 

  4. Gurley, K. A., Rink, J. C. & Sánchez Alvarado, A. Science 319, 323–327 (2008).

    Article  ADS  CAS  Google Scholar 

  5. Kumar, A., Godwin, J. W., Gates, P. B., Garza-Garcia, A. A. & Brockes, J. P. Science 318, 772–777 (2007).

    Article  ADS  CAS  Google Scholar 

  6. Morrison, J. I., Lööf, S., He, P. & Simon, A. J. Cell Biol. 172, 433–440 (2006).

    Article  CAS  Google Scholar 

  7. Reddien, P. W. et al. Dev. Cell 8, 635–649 (2005).

    Article  CAS  Google Scholar 

  8. Bryant, S. V., Endo, T. & Gardiner, D. M. Int. J. Dev. Biol. 46, 887–896 (2002).

    PubMed  Google Scholar 

  9. Tsonis, P. A., Madhavan, M., Tancous, E. E. & Del Rio-Tsonis, K. Int. J. Dev. Biol. 48, 975–980 (2004).

    Article  Google Scholar 

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Sánchez Alvarado, A. A cellular view of regeneration. Nature 460, 39–40 (2009).

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