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Obesity

Causes and control of excess body fat

Obesity is a major health problem in developed countries and a growing one in the developing world. It increases the risk of diabetes, heart disease, fatty liver and some forms of cancer. A better understanding of the biological basis of obesity should aid its prevention and treatment.

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Figure 1: Leptin and the control of body fat.
Figure 2: Feeding is a complex, motivational behaviour.

FURTHER READING

  1. Friedman, J. M. Modern science versus the stigma of obesity. Nature Med. 10, 563–569 (2004).

    CAS  Article  Google Scholar 

  2. Eckel, R. H. Clinical practice. Nonsurgical management of obesity in adults. N. Engl. J. Med. 358, 1941–1950 (2008).

    CAS  Article  Google Scholar 

  3. Coll, A. P., Farooqi, I. S. & O'Rahilly, S. The hormonal control of food intake. Cell 129, 251–262 (2007).

    CAS  Article  Google Scholar 

  4. Speakman, J. R. A nonadaptive scenario explaining the genetic predisposition to obesity: the 'predation release' hypothesis. Cell Metab. 6, 5–12 (2007).

    CAS  Article  Google Scholar 

  5. Farooqi, S. & O'Rahilly, S. Genetics of obesity in humans. Endocr. Rev. 27, 710–718 (2006).

    CAS  Article  Google Scholar 

  6. Friedman, J. M. A war on obesity, not the obese. Science 299, 856–858 (2003).

    ADS  CAS  Article  Google Scholar 

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Competing interests

Jeffery M. Friedman consults for Amylin Pharmaceuticals. He also has a financial interest in leptin through the Rockefeller University patent policy.

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Friedman, J. Causes and control of excess body fat. Nature 459, 340–342 (2009). https://doi.org/10.1038/459340a

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