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Causes and control of excess body fat

Obesity is a major health problem in developed countries and a growing one in the developing world. It increases the risk of diabetes, heart disease, fatty liver and some forms of cancer. A better understanding of the biological basis of obesity should aid its prevention and treatment.

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Figure 1: Leptin and the control of body fat.
Figure 2: Feeding is a complex, motivational behaviour.


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Competing interests

Jeffery M. Friedman consults for Amylin Pharmaceuticals. He also has a financial interest in leptin through the Rockefeller University patent policy.

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Friedman, J. Causes and control of excess body fat. Nature 459, 340–342 (2009).

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