Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Neuroscience

Optical control of reward

Is it wishful thinking that the behaviour of an organism as complex as a mouse might be controlled by modulating its intracellular signalling with light? No: this is just what researchers have achieved with an elegant technique.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: Light stimulation, intracellular signalling and regulation of function in neural networks.

References

  1. 1

    Airan, R. D., Thompson, K. R., Fenno, L. E., Bernstein, H. & Deisseroth, K. Nature 458, 1025–1029 (2009).

    ADS  CAS  Article  Google Scholar 

  2. 2

    Gradinaru, V. et al. J. Neurosci. 27, 14231–14238 (2007).

    CAS  Article  Google Scholar 

  3. 3

    Szobota, S. et al. Neuron 54, 535–545 (2007).

    CAS  Article  Google Scholar 

  4. 4

    Berndt, A., Yizhar, O., Gunaydin, L. A., Hegemann, P. & Deisseroth, K. Nature Neurosci. 12, 229–234 (2009).

    CAS  Article  Google Scholar 

  5. 5

    Cooper, J. R., Bloom, F. E. & Roth, R. H. in The Biochemical Basis of Neuropharmacology 8th edn (Oxford Univ. Press, 2003).

    Google Scholar 

  6. 6

    Bardo, M. T. & Bevins, R. A. Psychopharmacology 153, 31–43 (2000).

    CAS  Article  Google Scholar 

  7. 7

    Berridge, C. W. & Waterhouse, B. D. Brain Res. Brain Res. Rev. 42, 33–84 (2003).

    Article  Google Scholar 

  8. 8

    Surmeier, D. J., Ding, J., Day, M., Wang, Z. & Shen, W. Trends Neurosci. 30, 228–235 (2007).

    CAS  Article  Google Scholar 

  9. 9

    McClung, C. A. & Nestler, E. J. Neuropsychopharmacology 33, 3–17 (2008).

    CAS  Article  Google Scholar 

  10. 10

    Adamantidis, A. R., Zhang, F., Aravanis, A. M., Deisseroth, K. & de Lecea, L. Nature 450, 420–424 (2007).

    ADS  CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Moorman, D., Aston-Jones, G. Optical control of reward. Nature 458, 980–981 (2009). https://doi.org/10.1038/458980a

Download citation

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing