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Optical control of reward

Is it wishful thinking that the behaviour of an organism as complex as a mouse might be controlled by modulating its intracellular signalling with light? No: this is just what researchers have achieved with an elegant technique.

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Figure 1: Light stimulation, intracellular signalling and regulation of function in neural networks.


  1. 1

    Airan, R. D., Thompson, K. R., Fenno, L. E., Bernstein, H. & Deisseroth, K. Nature 458, 1025–1029 (2009).

    ADS  CAS  Article  Google Scholar 

  2. 2

    Gradinaru, V. et al. J. Neurosci. 27, 14231–14238 (2007).

    CAS  Article  Google Scholar 

  3. 3

    Szobota, S. et al. Neuron 54, 535–545 (2007).

    CAS  Article  Google Scholar 

  4. 4

    Berndt, A., Yizhar, O., Gunaydin, L. A., Hegemann, P. & Deisseroth, K. Nature Neurosci. 12, 229–234 (2009).

    CAS  Article  Google Scholar 

  5. 5

    Cooper, J. R., Bloom, F. E. & Roth, R. H. in The Biochemical Basis of Neuropharmacology 8th edn (Oxford Univ. Press, 2003).

    Google Scholar 

  6. 6

    Bardo, M. T. & Bevins, R. A. Psychopharmacology 153, 31–43 (2000).

    CAS  Article  Google Scholar 

  7. 7

    Berridge, C. W. & Waterhouse, B. D. Brain Res. Brain Res. Rev. 42, 33–84 (2003).

    Article  Google Scholar 

  8. 8

    Surmeier, D. J., Ding, J., Day, M., Wang, Z. & Shen, W. Trends Neurosci. 30, 228–235 (2007).

    CAS  Article  Google Scholar 

  9. 9

    McClung, C. A. & Nestler, E. J. Neuropsychopharmacology 33, 3–17 (2008).

    CAS  Article  Google Scholar 

  10. 10

    Adamantidis, A. R., Zhang, F., Aravanis, A. M., Deisseroth, K. & de Lecea, L. Nature 450, 420–424 (2007).

    ADS  CAS  Article  Google Scholar 

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Moorman, D., Aston-Jones, G. Optical control of reward. Nature 458, 980–981 (2009).

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