The spliceosome enzyme binds to RNA transcripts at splice sites and removes intron sequences. The crystal structure of a spliceosome subunit shows how the enzyme recognizes one end of the intron.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Pomeranz Krummel, D. A., Oubridge, C., Leung, A. K. W., Li, J. & Nagai, K. Nature 458, 475–480 (2009).
Lerner, M. R., Boyle, J. A., Mount, S. M., Wolin, S. L. & Steitz, J. A. Nature 283, 220–224 (1980).
Rogers, J. & Wall, R. Proc. Natl Acad. Sci. USA 77, 1877–1879 (1980).
Kambach, C. et al. Cell 96, 375–387 (1999).
Oubridge, C., Ito, N., Evans, P. R., Teo, C. H. & Nagai, K. Nature 372, 432–438 (1994).
Zhuang, Y. & Weiner, A. M. Cell 46, 827–835 (1986).
Du, H. & Rosbash, M. Nature 419, 86–90 (2002).
Chen, J. Y. et al. Mol. Cell 7, 227–232 (2001).
Staley, J. P. & Guthrie, C. Mol. Cell 3, 55–64 (1999).
Lamers, M. H. et al. Nature 407, 711–717 (2000).
Obmolova, G., Ban, C., Hsieh, P. & Yang, W. Nature 407, 703–710 (2000).
Kwek, K. Y. et al. Nature Struct. Biol. 9, 800–805 (2002).
Lewis, J. D., Izaurralde, E., Jarmolowski, A., McGuigan, C. & Mattaj, I. W. Genes Dev. 10, 1683–1698 (1996).
Shi, Y. et al. Mol. Cell 33, 365–376 (2009).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Query, C. Spliceosome subunit revealed. Nature 458, 418–419 (2009). https://doi.org/10.1038/458418a
Published:
Issue Date:
DOI: https://doi.org/10.1038/458418a
