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Motor-neuron disease

Rogue gene in the family

Nature volume 458, pages 415–416 (2009)Cite this article

Various gene mutations contribute to the motor-neuron disease known as amyotrophic lateral sclerosis. Further mutations that have been identified could help to clarify the neurodegenerative mechanism in this disorder.

At a time when it is not uncommon for genetic studies of human conditions to involve tens of thousands of individuals, and more than a million genomic variants associated with marginally higher or lower risks, studies involving just a handful of patients can still bring about a breakthrough. A testimony to this are two studies1,2published in Science, which report that the heritable form of the disease amyotrophic lateral sclerosis can be caused by mutations in the FUS gene.

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Authors and Affiliations

  1. Department of Molecular Genetics, Kristel Sleegers and Christine Van Broeckhoven are in the Neurodegenerative Brain Diseases Group, VIB, and in the Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp B-2610, Belgium. christine.vanbroeckhoven@molgen.vib-ua.be,

    Kristel Sleegers & Christine Van Broeckhoven

Authors
  1. Kristel Sleegers
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  2. Christine Van Broeckhoven
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Sleegers, K., Van Broeckhoven, C. Rogue gene in the family. Nature 458, 415–416 (2009). https://doi.org/10.1038/458415a

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