Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Circadian clocks

Tips from the tip of the iceberg

Daily remodelling of histone proteins underlies interactions between circadian clock genes and metabolic genes. This regulatory mechanism could be widespread, affecting other physiological processes.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Clock genes in health and disease.

References

  1. Alenghat, T. et al. Nature 456, 997–1000 (2008).

    Article  ADS  CAS  Google Scholar 

  2. Takahashi, J., Turek, F. & Moore, R. (eds) Handbook of Behavioural Neurobiology Vol. 12 (Kluwer Academic/Plenum, 2001).

    Book  Google Scholar 

  3. Panda, S. et al. Cell 109, 307–320 (2002).

    Article  CAS  Google Scholar 

  4. Turek, F. et al. Science 308, 1043–1045 (2005).

    Article  ADS  CAS  Google Scholar 

  5. Preitner, N. et al. Cell 110, 251–260 (2002).

    Article  CAS  Google Scholar 

  6. Ripperger, J. & Schibler, U. Nature Genet. 38, 369–374 (2006).

    Article  CAS  Google Scholar 

  7. Doi, M., Hirayama, J. & Sassone-Corsi, P. Cell 125, 497–508 (2006).

    Article  CAS  Google Scholar 

  8. Etchegaray, J. et al. Nature 421, 177–182 (2003).

    Article  ADS  CAS  Google Scholar 

  9. Ramsey, K. et al. Annu. Rev. Nutr. 27, 219–240 (2007).

    Article  CAS  Google Scholar 

  10. Naylor, E. et al. J. Neurosci. 20, 8138–8143 (2000).

    Article  CAS  Google Scholar 

  11. McClung, C. A. Pharmacol. Ther. 114, 222–232 (2007).

    Article  CAS  Google Scholar 

  12. Renthal, W. & Nestler, E. J. Trends Mol. Med. 14, 341–350 (2008).

    Article  CAS  Google Scholar 

  13. Sharma, R. Schizophr. Res. 72, 79–90 (2005).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Ethics declarations

Competing interests

The author has been a consultant and has received an honorarium and/or grant support from the following companies with an interest in sleep/circadian rhythms: Merck; Astra-Zeneca; Servier; Sanofi-Aventis, Resporonics; and Johnson & Johnson. He is also chief executive of (and holds equity in) a small company, NuNetix Inc., that works with pharmaceutical companies to test their compounds for effects on sleep and/or circadian rhythms.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Turek, F. Tips from the tip of the iceberg. Nature 456, 881–883 (2008). https://doi.org/10.1038/456881a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/456881a

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing