Research Highlights | Published:

Pharmacology: Setting the pace

Nature volume 456, page 549 (04 December 2008) | Download Citation

Subjects

A protein targeted by some diabetes drugs might also help to regulate daily cycles in blood pressure and heart rate.

Thiazolidinediones are widely prescribed for the treatment of type 2 diabetes, and work by activating a protein called PPAR-γ. Tianxin Yang of the University of Utah in Salt Lake City and his colleagues investigated the cardiovascular role of this protein using mice that lacked expression of the gene that encodes PPAR-γ in vascular smooth-muscle cells.

Rhythmic variations in blood pressure and heart rate, as well as in the expression of several body-clock genes in blood vessels, were diminished in these mice. Furthermore, normal mice treated with a thiazolidinedione called rosiglitazone showed increased expression of Bmal1, a clock gene.

About this article

Publication history

Published

DOI

https://doi.org/10.1038/456549a

Authors

    Comments

    By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

    Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing