Oncology: Odd ones out

    Article metrics

    Science doi:10.1126/science.1160165 (2008)

    By tracking the expression and location of almost 1,000 proteins in living cells, researchers have found new clues to how some cancer cells resist the chemotherapy drug camptothecin.

    Camptothecin targets a DNA-binding protein called TOP1. Ariel Cohen of the Weizmann Institute of Science in Rehovot, Israel, and his colleagues labelled proteins in human lung cancer cells with different fluorescent tags, and then tracked the proteins for two days after camptothecin treatment.

    About one out of every 10,000 cells survived the treatment. The reason seems to lie in the behaviour of two of the labelled proteins, DDX5 and RFC1, levels of which increased in surviving cells but decreased in those that died.

    Rights and permissions

    Reprints and Permissions

    About this article

    Cite this article

    Oncology: Odd ones out. Nature 456, 424–425 (2008) doi:10.1038/456424f

    Download citation

    Comments

    By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.