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Structural biology

Serpins' mystery solved

Polymers of misfolded proteins underlie many diseases, including major neurodegenerative disorders. Structural data on how such aggregates of serpin proteins form answer several outstanding questions.

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Figure 1: Serpin polymerization.

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Whisstock, J., Bottomley, S. Serpins' mystery solved. Nature 455, 1189–1190 (2008). https://doi.org/10.1038/4551189a

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