That genetic mutations contribute to cancer is undisputed. What now emerges is that a cancer cell's microenvironment has a much stronger hand in the course a cancer takes than previously thought.
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References
Weinberg, R. & Mihich, E. Cancer Res. 66, 11550–11553 (2006).
Tlsty, T. D. & Coussens, L. M. Annu. Rev. Pathol. 1, 119–150 (2006).
Finak, G. et al. Nature Med. 14, 518–527 (2008).
Postovit, L.-M. et al. Proc. Natl Acad. Sci. USA 105, 4329–4334 (2008).
Hu, M. et al. Cancer Cell 13, 394–406 (2008).
Paik, S. et al. N. Engl. J. Med. 351, 2817–2826 (2004).
Topczewska, J. M. et al. Nature Med. 12, 925–932 (2006).
Miller, F. R. J. Mammary Gland Biol. Neoplasia 5, 379–391 (2000).
Khalkhali-Ellis, Z. & Hendrix, M. J. Cancer Res. 67, 3535–3559 (2007).
Kerlikowske, K. et al. J. Natl Cancer Inst. 95, 1692–1702 (2003).
Gauthier, M. L. et al. Cancer Cell 12, 479–491 (2007).
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Tlsty, T. Whispering sweet somethings. Nature 453, 604–605 (2008). https://doi.org/10.1038/453604a
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DOI: https://doi.org/10.1038/453604a
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