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Whispering sweet somethings

That genetic mutations contribute to cancer is undisputed. What now emerges is that a cancer cell's microenvironment has a much stronger hand in the course a cancer takes than previously thought.

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  1. Weinberg, R. & Mihich, E. Cancer Res. 66, 11550–11553 (2006).

    CAS  Article  Google Scholar 

  2. Tlsty, T. D. & Coussens, L. M. Annu. Rev. Pathol. 1, 119–150 (2006).

    CAS  Article  Google Scholar 

  3. Finak, G. et al. Nature Med. 14, 518–527 (2008).

    CAS  Article  Google Scholar 

  4. Postovit, L.-M. et al. Proc. Natl Acad. Sci. USA 105, 4329–4334 (2008).

    CAS  Article  ADS  Google Scholar 

  5. Hu, M. et al. Cancer Cell 13, 394–406 (2008).

    CAS  Article  Google Scholar 

  6. Paik, S. et al. N. Engl. J. Med. 351, 2817–2826 (2004).

    CAS  Article  Google Scholar 

  7. Topczewska, J. M. et al. Nature Med. 12, 925–932 (2006).

    CAS  Article  Google Scholar 

  8. Miller, F. R. J. Mammary Gland Biol. Neoplasia 5, 379–391 (2000).

  9. Khalkhali-Ellis, Z. & Hendrix, M. J. Cancer Res. 67, 3535–3559 (2007).

    CAS  Article  Google Scholar 

  10. Kerlikowske, K. et al. J. Natl Cancer Inst. 95, 1692–1702 (2003).

    Article  Google Scholar 

  11. Gauthier, M. L. et al. Cancer Cell 12, 479–491 (2007).

    CAS  Article  Google Scholar 

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Tlsty, T. Whispering sweet somethings. Nature 453, 604–605 (2008).

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