Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Molecular biology

Genome under surveillance

Decoding the information stored in DNA requires an intricate balance between processes that turn gene expression on or off. A protein that influences the packaging of DNA regulates this balance genome-wide.

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: The Isw2 protein represses transcription by altering nucleosome positions.


  1. Whitehouse, I., Rando, O. J., Delrow, J. & Tsukiyama, T. Nature 450, 1031–1035 (2007).

    Article  CAS  ADS  Google Scholar 

  2. Yuan, G.-C. et al. Science 309, 626–630 (2005).

    Article  CAS  ADS  Google Scholar 

  3. Lee, W. et al. Nature Genet. 39, 1235–1244 (2007).

    Article  CAS  Google Scholar 

  4. Segal, E. et al. Nature 442, 772–778 (2006).

    Article  CAS  ADS  Google Scholar 

  5. Ioshikhes, I. P., Albert, I., Zanton, S. J. & Pugh, B. F. Nature Genet. 38, 1210–1215 (2006).

    Article  CAS  Google Scholar 

  6. Saha, A., Wittmeyer, J. & Cairns, B. R. Nature Rev. Mol. Cell Biol. 7, 437–447 (2006).

    Article  CAS  Google Scholar 

  7. Whitehouse, I. & Tsukiyama, T. Nature Struct. Mol. Biol. 13, 633–640 (2006).

    Article  CAS  Google Scholar 

  8. Goldmark, J. P., Fazzio, T. G., Estep, P. W., Church, G. M. & Tsukiyama, T. Cell 103, 423–433 (2000).

    Article  CAS  Google Scholar 

  9. Raisner, R. M. & Madhani, H. D. Curr. Opin. Genet. Dev. 16, 119–124 (2006).

    Article  CAS  Google Scholar 

  10. Alén, C. et al. Mol. Cell 10, 1441–1452 (2002).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

Arndt, K. Genome under surveillance. Nature 450, 959–960 (2007).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing