Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

New uses for old drugs

It takes too long and costs too much to bring new drugs to market. So let's beef up efforts to screen existing drugs for new uses, argue Curtis R. Chong and David J. Sullivan Jr.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1

References

  1. DiMasi, J. A., Hansen, R. W. & Grabowski, H. G. J. Health Econ. 22, 151–185 (2003).

    Article  Google Scholar 

  2. Cohen, F. J. Nature Rev. Drug Discov. 4, 78–84 (2005).

    Article  CAS  Google Scholar 

  3. Ashburn, T. T. & Thor, K. B. Nature Rev. Drug Discov. 3, 673–683 (2004).

    Article  CAS  Google Scholar 

  4. Rothstein, J. D. et al. Nature 433, 73–77 (2005).

    Article  ADS  CAS  Google Scholar 

  5. Moran, M. PLoS Med. 2, e302 (2005).

    Article  Google Scholar 

  6. Sundar, S. et al. N. Engl. J. Med. 347, 1739–1746 (2002).

    Article  CAS  Google Scholar 

  7. Chong, C. R. et al. Nature Chem. Biol. 2, 415–416 (2006).

    Article  CAS  Google Scholar 

  8. Lipinski, C. A. et al. Adv. Drug Deliv. Rev. 46, 3–26 (2001).

    Article  CAS  Google Scholar 

  9. Sussman, G. L. et al. J. Allergy Clin. Immunol. 104, 100–106 (1999).

    Article  CAS  Google Scholar 

  10. Weber, W. W. Mol. Diagn. 4, 299–307 (1999).

    Article  CAS  Google Scholar 

  11. Voigt, J. H. et al. J. Chem. Inf. Comput. Sci. 41, 702–712 (2001).

    Article  CAS  Google Scholar 

  12. Wishart, D. S. et al. Nucleic Acids Res. 34, D668–D672 (2006).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We thank Walter Pudelko for invaluable help with Supplementary Table 2.

Author information

Authors and Affiliations

Authors

Supplementary information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Chong, C., Sullivan, D. New uses for old drugs. Nature 448, 645–646 (2007). https://doi.org/10.1038/448645a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/448645a

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing