It takes too long and costs too much to bring new drugs to market. So let's beef up efforts to screen existing drugs for new uses, argue Curtis R. Chong and David J. Sullivan Jr.
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References
DiMasi, J. A., Hansen, R. W. & Grabowski, H. G. J. Health Econ. 22, 151–185 (2003).
Cohen, F. J. Nature Rev. Drug Discov. 4, 78–84 (2005).
Ashburn, T. T. & Thor, K. B. Nature Rev. Drug Discov. 3, 673–683 (2004).
Rothstein, J. D. et al. Nature 433, 73–77 (2005).
Moran, M. PLoS Med. 2, e302 (2005).
Sundar, S. et al. N. Engl. J. Med. 347, 1739–1746 (2002).
Chong, C. R. et al. Nature Chem. Biol. 2, 415–416 (2006).
Lipinski, C. A. et al. Adv. Drug Deliv. Rev. 46, 3–26 (2001).
Sussman, G. L. et al. J. Allergy Clin. Immunol. 104, 100–106 (1999).
Weber, W. W. Mol. Diagn. 4, 299–307 (1999).
Voigt, J. H. et al. J. Chem. Inf. Comput. Sci. 41, 702–712 (2001).
Wishart, D. S. et al. Nucleic Acids Res. 34, D668–D672 (2006).
Acknowledgements
We thank Walter Pudelko for invaluable help with Supplementary Table 2.
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Chong, C., Sullivan, D. New uses for old drugs. Nature 448, 645–646 (2007). https://doi.org/10.1038/448645a
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DOI: https://doi.org/10.1038/448645a
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