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Cell biology

Lost in mitotic translation

A Correction to this article was published on 18 April 2007

A protein called 14-3-3σ inhibits the cell cycle and may act as a tumour suppressor. It now turns out that it is also involved in regulating protein synthesis from messenger RNA during cell division.

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Figure 1: Role of the 14-3-3σ protein in cap-dependent and cap-independent mRNA translation.


  1. Holcik, M. & Sonenberg, N. Nature Rev. Mol. Cell Biol. 6, 318–327 (2005).

    CAS  Article  Google Scholar 

  2. Wilker, E. W. et al. Nature 446, 329–332 (2007).

    ADS  CAS  Article  Google Scholar 

  3. Pyronnet, S. et al. Genes Dev. 15, 2083–2093 (2001).

    CAS  Article  Google Scholar 

  4. Pyronnet, S. et al. Mol. Cell 5, 607–616 (2000).

    CAS  Article  Google Scholar 

  5. Darling, D. L., Yingling, J. & Wynshaw-Boris, A. Curr. Top. Dev. Biol. 68, 281–315 (2005).

    CAS  Article  Google Scholar 

  6. Hermeking, H. et al. Mol. Cell 1, 3–11 (1997).

    CAS  Article  Google Scholar 

  7. Chan, T. A. et al. Nature 401, 616–620 (1999).

    ADS  CAS  Article  Google Scholar 

  8. Lodygin, D. & Hermeking, H. Cell Res. 15, 237–246 (2005).

    CAS  Article  Google Scholar 

  9. Cornelius, S. et al. Mol. Cell 5, 597–605 (2000).

    Article  Google Scholar 

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Wynshaw-Boris, A. Lost in mitotic translation. Nature 446, 274–275 (2007).

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