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Developmental neurobiology

A destructive switch for neurons

In the developing nervous system, tremendous multiplication and diversification of cells elaborate the exquisite pattern of the brain. But how do cells shift from early proliferation to assume their mature states?

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Figure 1: Protein destruction in post-mitotic neurons.
Figure 2: A model for destruction of inhibitors of neuronal differentiation.

References

  1. Lasorella, A. et al. Nature 442, 471–474 (2006).

    Article  ADS  CAS  PubMed  Google Scholar 

  2. Yokota, Y. Oncogene 20, 8290–8298 (2001).

    Article  CAS  PubMed  Google Scholar 

  3. Peters, J. M. Mol. Cell 9, 931–943 (2002).

    Article  CAS  PubMed  Google Scholar 

  4. Jackson, P. K. et al. Trends Cell Biol. 10, 429–439 (2000).

    Article  CAS  PubMed  Google Scholar 

  5. Gieffers, C. et al. Proc. Natl Acad. Sci. USA 96, 11317–11322 (1999).

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  6. Yamano, H. et al. Mol. Cell 16, 137–147 (2004).

    Article  Google Scholar 

  7. Konishi, Y. et al. Science 303, 1026–1030 (2004).

    Article  ADS  CAS  PubMed  Google Scholar 

  8. Stegmuller, J. et al. Neuron 50, 389–400 (2006).

    Article  CAS  PubMed  Google Scholar 

  9. Juo, P. & Kaplan, J. M. Curr. Biol. 14, 2057–2062 (2004).

    Article  CAS  PubMed  Google Scholar 

  10. van Roessel, P. et al. Cell 119, 707–718 (2004).

    Article  CAS  PubMed  Google Scholar 

Download references

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Jackson, P. A destructive switch for neurons. Nature 442, 365–366 (2006). https://doi.org/10.1038/442365a

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